At Lucas Oil Stadium, Indianapolis:
Quarterback Brock Purdy completed 25 of 34 passes for five touchdowns (two to Christian McCaffery) as the San Francisco 49ers (11-4) pulled away from the Indianapolis Colts (8-7) in the second half to post a 48-27 road victory.
Christian McCaffery ran for 117 yards in the game.
The Colts' defeat enabled the Jacksonville Jaguars, Buffalo Bills, and Los Angeles Chargers to clinch playoff berths.
Next for the Niners, a big encounter at home with the Chicago Bears (11-4) this coming Sunday (5:20 PM PST, NBC/Peacock).
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