At San Francisco:
Quarterback Alex Smith completed 15 of 20 passes for 124 yards and ran one yard for a touchdown, while Ted Ginn, Jr. returned a kickoff for 102 and a TD and a punt 55 yards for another score as the San Francisco 49ers, in Jim Harbaugh's debut as an NFL head coach, defeated the visiting Seattle Seahawks 33-17 in the National Football League regular-season opener for both teams on Sunday.
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